

Meta-Sitosterol™ 2.0 – Plant Sterols & Folate for Cholesterol and Cardiovascular Support
Support your cardiovascular health with Meta-Sitosterol™ 2.0, a vegetarian-friendly formula featuring 2 grams of plant sterols per daily dose—an amount consistent with NIH recommendations for helping to maintain healthy cholesterol levels already within a normal range*. This advanced formula also includes L-5-methyltetrahydrofolate, the active and bioavailable form of folate, to support homocysteine metabolism and promote overall heart health.*
❤️ Key Benefits:
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✅ Provides 2 grams of plant sterols daily, consistent with NIH guidance*
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✅ Supports healthy total and LDL cholesterol levels within a normal range*
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✅ Contains L-5-MTHF, the preferred active form of folate*
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✅ Supports homocysteine clearance for enhanced cardiovascular protection*
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✅ Gluten-free and vegetarian-friendly formulation
🧪 How It Works:
Plant sterols are naturally occurring compounds found in vegetables and legumes. Structurally similar to cholesterol, they help block the absorption of dietary cholesterol in the intestines—reducing the amount that enters the bloodstream.*
L-5-methyltetrahydrofolate (L-5-MTHF) plays a crucial role in converting homocysteine to methionine, a process vital to maintaining healthy vascular integrity and reducing cardiovascular risk factors.*
💊 Suggested Use:
Take 1 tablet with each meal, or as directed by your healthcare provider.
Serving Size: 1 Tablet
Daily Plant Sterol Intake: 2 grams (across 3 tablets per day)
🧾 Ingredients:
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Plant Sterol Complex (soy) – primary active ingredient
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Calcium L-5-methyltetrahydrofolate – active folate
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Other Ingredients: Microcrystalline cellulose, croscarmellose sodium, cellulose, vegetable stearic acid, silica
✅ Gluten-free
✅ Vegetarian
❌ Contains soy
⚠️ Do not refrigerate (moisture may degrade product)
Feature / Benefit | Meta-Sitosterol™ 2.0 | Red Yeast Rice | Statin Medications |
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Primary Mechanism | Blocks cholesterol absorption in intestines | Inhibits cholesterol production in liver | Inhibits HMG-CoA reductase (cholesterol enzyme) |
Contains Plant Sterols | ✅ Yes (2g daily) | ❌ No | ❌ No |
Includes Active Folate (L-5-MTHF) | ✅ Yes | ❌ No | ❌ No |
Supports Homocysteine Metabolism | ✅ Yes | ❌ No | ❌ No |
Proven to Lower LDL | ✅ Clinically backed | ✅ Moderate | ✅ Strong |
FDA Approved | ❌ No (Dietary supplement) | ❌ No (Dietary supplement) | ✅ Yes |
Requires Prescription | ❌ No | ❌ No | ✅ Yes |
Side Effect Risk | ⚠️ Very Low | ⚠️ Moderate (risk of myopathy or liver enzymes) | ⚠️ Higher (muscle pain, liver enzyme elevation) |
Drug-Nutrient Interactions | ❌ Minimal | ⚠️ Possible (grapefruit, CoQ-10 depletion) | ✅ Common |
Best For | Mild to moderate cholesterol support; preventive care | Moderate support; some cholesterol reduction | High cholesterol requiring aggressive treatment |
Meta-Sitosterol 2 – FAQs
What is Meta-Sitosterol 2 and how do plant sterols (β-sitosterol) support healthy cholesterol?
Meta-Sitosterol 2 cholesterol support provides concentrated plant sterols (including beta-sitosterol) to help maintain healthy LDL cholesterol already within the normal range. Plant sterols are natural compounds from plants that support heart-healthy lipids as part of diet and lifestyle.
How do plant sterols work to support LDL cholesterol levels?
Plant sterols compete with dietary cholesterol for absorption in the gut, which helps maintain healthy LDL cholesterol. For best results, pair beta-sitosterol supplements with a heart-smart diet and regular movement.
What dosage and timing are best for Meta-Sitosterol 2?
Follow this product’s label for your Meta-Sitosterol 2 dosage. Many sterol formulas are taken with meals that contain fats, since that’s when dietary cholesterol absorption occurs. Consistency is key for ongoing cholesterol support.
How long until I notice changes in cholesterol with plant sterols?
Most people evaluate plant sterol routines over 4–8 weeks alongside diet and exercise. Work with your clinician on lab timing and personalized goals for lipid support.
Can I take Meta-Sitosterol 2 with statins or other cholesterol medications?
Many use plant sterols with statins under professional guidance. Always consult your healthcare provider before combining a cholesterol support supplement with prescriptions; supplements don’t replace prescribed therapy.
Does beta-sitosterol affect HDL or triglycerides?
Beta-sitosterol primarily supports LDL. Effects on HDL cholesterol and triglycerides are typically modest; your overall diet (omega-3s, fiber) and activity play a larger role.
Are there precautions—who should avoid plant sterols?
Do not use if you have the rare condition sitosterolemia. Talk to your clinician if pregnant, nursing, or managing medical conditions. Because sterols may slightly reduce absorption of fat-soluble vitamins (A, D, E, K), consider taking those at a different time of day.
Is Meta-Sitosterol 2 non-GMO and suitable for special diets or allergies?
Check this page’s Supplement Facts and ingredient list for excipients and allergen statements. Many shoppers look for non-GMO plant sterols and gluten-conscious options—verify the label or contact support if you have sensitivities.